January 18, 2026 · 6 min read
What is TB-500? Thymosin Beta-4 Research Explained
TB-500 is a synthetic fragment of Thymosin Beta-4, one of the most studied peptides in cell-migration research.
What is TB-500?
TB-500 is a synthetic fragment of Thymosin Beta-4, a naturally occurring 43-amino-acid actin-sequestering peptide expressed in nearly every human tissue. TB-500 contains the biologically active region responsible for actin monomer binding.
Mechanism of action
By binding G-actin, TB-500 promotes cytoskeletal remodeling, endothelial migration and progenitor cell mobilization — pathways that underpin wound healing, cardiac repair and hair follicle stem cell activation in preclinical research.
TB-500 and BPC-157 stacks
In published research protocols, TB-500 is frequently paired with BPC-157 because the two peptides target complementary repair pathways. Peptana offers this stack pre-blended as the Wolverine Blend.
Buying TB-500
Peptana TB-500 is HPLC tested to ≥99% purity with mass-spec identity confirmation and a downloadable Certificate of Analysis for every lot.
Featured research peptide
TB-500 — 10 mg
TB-500 is a synthetic fragment of the naturally occurring protein Thymosin Beta-4. It is widely used in research focused on actin regulation, cell migration, and wound-healing pathways.