TB-500 (Thymosin Beta-4): Mechanism & Repair Research
TB-500 is a synthetic fragment of Thymosin Beta-4, a naturally occurring 43-amino-acid actin-sequestering peptide involved in cellular migration, wound healing and angiogenesis.
Mechanism of action
TB-500 binds G-actin monomers, promoting cytoskeletal remodeling and directed cell migration. Preclinical models demonstrate upregulation of endothelial migration, myocardial progenitor mobilization and hair follicle stem-cell activation.
Research benefits
- Enhanced fibroblast and keratinocyte migration in wound models
- Cardiac progenitor cell mobilization after ischemic injury
- Hair follicle stem cell activation in dermal research
- Anti-inflammatory activity through actin-dependent pathways
Selected studies & citations
Thymosin Beta-4 in cardiac repair
TB4 mobilized epicardial progenitors and improved cardiac function post-MI in mice.
Smart N, et al. Nature. 2007.
TB4 promotes dermal wound closure
Accelerated re-epithelialization and angiogenesis in full-thickness wound models.
Malinda KM, et al. FASEB J. 1999.
Safety & handling
Preclinical toxicology of TB-500 shows favorable tolerability at research doses. Peptana material is sold for in-vitro and preclinical use only.