Peptide science
NAD+ Research: Mitochondria, Sirtuins & Longevity
Nicotinamide Adenine Dinucleotide (NAD+) is a central redox coenzyme in every living cell, essential for electron transport, sirtuin activity and DNA repair enzyme PARP function.
Mechanism of action
NAD+ acts as an electron acceptor in glycolysis, the TCA cycle and oxidative phosphorylation. It is the required substrate for the sirtuin family of NAD-dependent deacetylases, which regulate metabolic and longevity pathways.
Research benefits
- Support of mitochondrial oxidative phosphorylation
- Substrate for sirtuin-mediated deacetylation
- PARP-dependent DNA repair signaling
- Studied in models of age-related metabolic decline
Selected studies & citations
NAD+ decline with age
Cellular NAD+ levels drop significantly with age in multiple tissues.
Gomes AP, et al. Cell. 2013.
NAD+ precursors extend lifespan in mice
NAD+ boosting restored mitochondrial function and improved lifespan endpoints.
Zhang H, et al. Science. 2016.
Safety & handling
NAD+ and its precursors have a favorable safety profile in preclinical models. Peptana NAD+ is sold for in-vitro research only.